Weiss B F, Munro H N, Wurtman R J
Science. 1971 Aug 27;173(3999):833-5. doi: 10.1126/science.173.3999.833.
One hour after administration of L-dopa (50 to 300 milligrams per kilogram), there is a marked disaggregation of brain polysomes in immature rats. Adult animals show a similar response, but require larger doses of the amino acid (500 milligrams per kilogram). Single doses of L-dopa significantly elevate amounts of tryptophan in the brain; hence their effect on polysomes does not result from the unavailability of this amino acid.
给未成熟大鼠注射左旋多巴（每千克50至300毫克）一小时后，其脑多核糖体出现明显解聚。成年动物也有类似反应，但需要更大剂量的该氨基酸（每千克500毫克）。单次注射左旋多巴可显著提高脑中色氨酸的含量；因此，它们对多核糖体的作用并非源于这种氨基酸的缺乏。
