尼古丁对兔腮腺唾液淀粉酶分泌的影响。
Effects of nicotine on salivary amylase secretion from rabbit parotid gland.
作者信息
Inoki R, Kojima S, Tamari Y, Yamamoto I
出版信息
Br J Pharmacol. 1971 Feb;41(2):285-93. doi: 10.1111/j.1476-5381.1971.tb08029.x.
Abstract
- The effects of nicotine on amylase secretion induced by auriculo-temporal nerve stimulation were studied.2. Nicotine caused a transient increase in secretion as well as flow rate of amylase.3. No difference in nicotine action was found between acute sympathetic decentralization of the gland and acute denervation.4. The increase in amylase secretion due to nicotine was not inhibited by phenoxybenzamine, bretylium and chronic denervation, but was prevented by hexamethonium, propranolol and adrenalectomy.5. The increase in flow rate due to nicotine was not inhibited by propranolol, chronic denervation and adrenalectomy, but was prevented by hexamethonium, phenoxybenzamine and bretylium.6. These results show that the action of nicotine in increasing amylase secretion is neither a direct action on the ganglion nor on the nerve terminal of the cervical sympathetic nerve, but is an indirect action of catecholamines released from the adrenal medulla on the post-junctional receptors.7. The study also suggests that the initial acceleration of salivary flow due to nicotine is characterized by a mechanism different from that of amylase secretion.
摘要
研究了尼古丁对耳颞神经刺激诱导的淀粉酶分泌的影响。
尼古丁导致淀粉酶分泌及流速短暂增加。
在腺体急性交感神经去传入和急性去神经支配之间，未发现尼古丁作用有差异。
尼古丁引起的淀粉酶分泌增加不受酚苄明、溴苄铵和慢性去神经支配的抑制，但六甲铵、普萘洛尔和肾上腺切除术可阻止其增加。
尼古丁引起的流速增加不受普萘洛尔、慢性去神经支配和肾上腺切除术的抑制，但六甲铵、酚苄明和溴苄铵可阻止其增加。
这些结果表明，尼古丁增加淀粉酶分泌的作用既不是对神经节的直接作用，也不是对颈交感神经神经末梢的直接作用，而是肾上腺髓质释放的儿茶酚胺对节后受体的间接作用。
该研究还表明，尼古丁引起的唾液流速初始加速的机制与淀粉酶分泌的机制不同。
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