Rudolph A M
Br Heart J. 1971;33(Suppl):Suppl:32-4. doi: 10.1136/hrt.33.suppl.32.
The haemodynamic effects and clinical manifestations of congenital heart lesions may be greatly influenced by developmental changes in the circulation. The sequential changes associated with abnormal communications between the systemic and pulmonary circulations are well typified by the effect on ventricular septal defect. The possible influences of ventricular septal defect on the foetal circulation are first presented, and the interrelationship between ventricular septal defect and postnatal adjustments of the circulation are discussed.
先天性心脏病变的血流动力学效应及临床表现可能会受到循环系统发育变化的显著影响。体循环与肺循环之间异常交通所伴随的一系列变化，在室间隔缺损的影响中得到了很好的体现。首先阐述室间隔缺损对胎儿循环可能产生的影响，然后讨论室间隔缺损与出生后循环调整之间的相互关系。
