Oh K S, Park S C, Galvis A G, Young L W, Neches W H, Zuberbuhler J R
J Thorac Cardiovasc Surg. 1978 Nov;76(5):706-9.
Pulmonary hyperinflation (PH) has frequently been seen in patients with ventricular septal defect (VSD). Mean age of patients at the time of cardiac catherization and operation was less in Group II (PHI) than in Group I (normal pulmonary inflation). There is a statistically significant difference in the ratio of mean pulmonary to mean systemic blood flow and the ratio of mean peak pulmonary to mean peak systemic systolic pressures, with the higher values recorded for Group II. There is no statistically significant difference in the pulmonary vascular resistance in the two groups. Thirty-five of the 44 patients with PHI developed normal inflation within a month after surgical correction of VSD. Possible mechanisms of PHI in VSD are discussed. PHI is prolong and perpetuate respiratory distress and can lead to progressive lung disease. PHI is therefore another indication for early surgical correction of VSD.
肺过度充气（PH）在室间隔缺损（VSD）患者中很常见。与第一组（正常肺充气）相比，第二组（PHI）患者在心脏导管检查和手术时的平均年龄较小。平均肺血流量与平均体循环血流量之比以及平均肺峰值与平均体循环收缩压峰值之比存在统计学显著差异，第二组的数值更高。两组的肺血管阻力无统计学显著差异。44例PHI患者中有35例在VSD手术矫正后一个月内肺充气恢复正常。文中讨论了VSD中PHI的可能机制。PHI会延长并持续呼吸窘迫，并可能导致进行性肺部疾病。因此，PHI是VSD早期手术矫正的另一个指征。
