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[产后起病的精神分裂症患者的免疫病理原理状况]

[Sate of immunopathologic principles in patients whose schizophrenia commenced after childbirth].

作者信息

Semenov S F, Pashutova E K

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(1):72-8.

PMID:557274
Abstract

On the basis of comprehensive immuno-biological studies of schizophrenia where the disease manifests itself after delivery, the authors come to the conclusion that a certain role is played in the development of the disease by immuno-allergic processes. Facts confirming this supposition are a detection of brain antigens and the expressiveness of sensitization even during the initial stage of the disease, a sufficiently high frequency of revealed automtibodies, their correlation with the quality to remissions. Besides these facts, the authors were able to distinguish individually different types of antibody formation in recurrent and attack-like-progressive forms of schizophrenia, a fall in the complement activity in the blood serum of patients as well as a certain connection between the indicis of organopecific immunity and the dynamics of the morbid process.

摘要

基于对产后发病的精神分裂症进行的全面免疫生物学研究,作者得出结论:免疫过敏过程在该疾病的发展中起一定作用。证实这一假设的事实包括,即使在疾病初期也检测到脑抗原和致敏的表现、自身抗体的检出频率足够高、它们与缓解质量的相关性。除了这些事实外,作者还能够区分精神分裂症复发型和发作样进行型中个体不同类型的抗体形成、患者血清中补体活性的下降以及器官特异性免疫指标与病程动态之间的某种联系。

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