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[精神分裂症患者血清中的脑自身抗原]

[Cerebral auto-antigens in the serum of schizophrenic patients].

作者信息

Popova N A

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1976 Apr;76(4):543-9.

PMID:936849
Abstract

Brain autoantigens in the blood of 200 schizophrenic patients were investigated. It was established that the introduction of brain autoantigens caused the formation of antibrain antibodies in the animals. The brain autoantigen, limitted by the species, is also present, and there is a possibility of autoimmunization by each of them. It is shown that the autoantigen which is connected with the species of the brain, is stable to organic dissolvent activity in the paranoid form of schizophrenia (87.5%) and in the malignant and shift-like form (20%). In the other forms of schizophrenia and also in epilepsy and viluy encephalitis its inactivation is marked. The qualitative heterogeneity of brain autoantigen in different forms of schizophrenia is suggested.

摘要

对200名精神分裂症患者血液中的脑自身抗原进行了研究。已证实,向动物体内引入脑自身抗原会导致抗脑抗体的形成。受物种限制的脑自身抗原也存在,并且它们中的每一种都有可能引发自身免疫。结果表明,与脑的物种相关的自身抗原,在偏执型精神分裂症(87.5%)以及恶性和交替型精神分裂症(20%)中对有机溶剂活性稳定。在其他形式的精神分裂症以及癫痫和维柳伊脑炎中,其失活明显。提示了不同形式精神分裂症中脑自身抗原的质量异质性。

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