Dvorchik B H, Istin M, Maren T H
Science. 1971 May 14;172(3984):728-9. doi: 10.1126/science.172.3984.728.
At a concentration of 50 to 100 micrograms per milliliter, p,p'-DDT (and p,p'-DDE) did not inhibit the rate of hydration or dehydration of carbon dioxide by carbonic anhydrase. At concentrations greater than 500 micrograms per milliliter, partial inhibition of the rate of dehydration of carbonic acid was observed, but this involved precipitation of drug in the reaction vessel. This degree of inhibition suggests that DDT may not inhibit carbonic anhydrase effectively at the usual concentrations found in tissue after exposure of organisms to DDT in the environment.
在浓度为每毫升50至100微克时，对，对'-滴滴涕（以及对，对'-滴滴伊）不会抑制碳酸酐酶催化二氧化碳水合或脱水的速率。在浓度高于每毫升500微克时，观察到碳酸脱水速率受到部分抑制，但这涉及到反应容器中药物的沉淀。这种抑制程度表明，在生物体于环境中接触滴滴涕后，组织中通常发现的浓度下，滴滴涕可能无法有效抑制碳酸酐酶。
