Devenport L D, Balagura S
Science. 1971 May 14;172(3984):744-6. doi: 10.1126/science.172.3984.744.
In contrast to the existing views of lateral hypothalamic function, food motivated behavior appears to be greatly enhanced in animals that have recovered from lateral hypothalamic lesions. In a familiar environment, these rats begin eating 4.8 times sooner than normal controls, 5.6 times faster than hyperphagic rats that have received ventromedial hypothalamic lesions, and 4.7 times faster than animals with septal lesions. The same relation holds for latencies to eat in a novel environment and for rate of acquisition of a simple food-rewarded discrimination task. The concept of a lateral hypothalamic "hunger center" is questioned.
与下丘脑外侧功能的现有观点相反，在从下丘脑外侧损伤中恢复的动物中，受食物驱动的行为似乎大大增强。在熟悉的环境中，这些大鼠开始进食的时间比正常对照组早4.8倍，比接受腹内侧下丘脑损伤的食欲亢进大鼠快5.6倍，比有隔区损伤的动物快4.7倍。在新环境中的进食潜伏期以及简单食物奖励辨别任务的习得率方面，也存在同样的关系。下丘脑外侧“饥饿中枢”的概念受到质疑。
