Sclafani A, Berner C N, Maul G
J Comp Physiol Psychol. 1975 Jan;88(1):201-7.
Single or multiple sets of bilateral knife cuts were made in female rats just lateral to the ventromedial hypothalamus (VMH) and/or just medial to the lateral hypothalamus (LH). The lateral VMH cuts by themselves produced greater hyperphagia and obesity than did the medial LH cuts. The lateral VMH knife cuts also significantly increased food intake and body weight in rats previously given bilateral cuts along the medial LH border. These findings indicate that the feeding inhibitory fibers responsible for the hyperphagia syndrome do not project from the VMH to the LH, and this calls for a reevaluation of hypothalamic circuitry. It was also discovered that sham surgery has a significant suppressive effect on the hyperphagia syndrome produced by hypothalamic knife cuts.
在雌性大鼠中，于腹内侧下丘脑（VMH）外侧和/或下丘脑外侧（LH）内侧进行单组或多组双侧刀割。单独进行VMH外侧的刀割比LH内侧的刀割产生更严重的食欲亢进和肥胖。对于先前已沿LH内侧边界进行双侧刀割的大鼠，VMH外侧的刀割也显著增加了食物摄入量和体重。这些发现表明，导致食欲亢进综合征的摄食抑制纤维并非从VMH投射至LH，这需要对下丘脑回路进行重新评估。还发现假手术对下丘脑刀割所产生的食欲亢进综合征具有显著的抑制作用。
