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免疫偏离:通过抑制巨噬细胞迁移在体外证明分裂耐受性。

Immune deviation: demonstration of split tolerance in vitro by inhibition of macrophage migration.

作者信息

Dasgupta A

出版信息

Clin Exp Immunol. 1971 Feb;8(2):173-6.

Abstract

Migration of cells, taken from animals immunized with ovalbumin in Freund's complete adjuvant which gave normal delayed hypersensitivity skin responses, was found to be significantly inhibited in the presence of antigen. Migration of peritoneal exudate cells from guinea-pigs in which immune deviation had been induced by immunization with antigen in Freund's incomplete adjuvant was not inhibited.

摘要

取自在弗氏完全佐剂中用卵清蛋白免疫且产生正常迟发型超敏皮肤反应的动物的细胞,发现在有抗原存在的情况下其迁移受到显著抑制。来自豚鼠的腹腔渗出细胞的迁移未受抑制,这些豚鼠是通过在弗氏不完全佐剂中用抗原免疫而诱导产生免疫偏离的。

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本文引用的文献

1
Studies in experimental immunology of influenza. VII. An improved complement-fixation technique.
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[A micro-method of immuno-electrophoresis].
Int Arch Allergy Appl Immunol. 1955;7(2):103-10.
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Suppression of delayed hypersensitivity in vitro by inhibition of protein synthesis.
J Exp Med. 1965 Dec 1;122(6):1125-34. doi: 10.1084/jem.122.6.1125.

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