临床化学值的遗传变异性。
Genetic variability of clinical chemical values.
作者信息
Havlik R, Garrison R, Fabsitz R, Feinleib M
出版信息
Clin Chem. 1977;23(4):659-62.
A study of cardiovascular risk factors in middle-aged twin men provided an opportunity to test for genetic variability in the SMA 12/60 (Technicon) battery of clinical chemistry tests. Classical twin methodology was used to analyze the variation of monozygotic and dizygotic twins. In addition, frequency of co-twin contact was used to control for effects of differences in shared environment. Genetic variability played a definite role in controlling four of the 11 reported tests: one-hour serum glucose, serum urea nitrogen, uric acid, and bilirubin. No genetic variation was found for lactate dehydrogenase, phosphorus, and alkaline phosphatase. Significantly higher means for calcium, total protein, albumin, and aspartate aminotransferase in monozygotic twins precluded any statement about heredity and environment for these tests.
一项针对中年男性双胞胎心血管危险因素的研究，提供了一个机会来检测临床化学检测SMA 12/60（Technicon）系列中基因变异情况。采用经典双胞胎研究方法分析同卵双胞胎和异卵双胞胎的变异情况。此外，通过双胞胎接触频率来控制共享环境差异的影响。基因变异在11项报告检测中的4项检测中发挥了明确作用：1小时血清葡萄糖、血清尿素氮、尿酸和胆红素。未发现乳酸脱氢酶、磷和碱性磷酸酶存在基因变异。同卵双胞胎中钙、总蛋白、白蛋白和天冬氨酸转氨酶的均值显著更高，因此无法就这些检测的遗传和环境因素作出任何说明。
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