巴西双胞胎17种血清生化性状的遗传和环境决定因素

Genetic and environmental determinants of 17 serum biochemical traits in Brazilian twins.

作者信息

Dal Colletto G M, Krieger H, Magalhães J R

出版信息

Acta Genet Med Gemellol (Roma). 1983;32(1):23-9. doi: 10.1017/s0001566000008126.

Abstract

The genetic and environmental effects on the levels of 17 serum biochemical quantitative traits (calcium, phosphorus, glucose, urea nitrogen, uric acid, total protein, albumin, total bilirubin, alkaline phosphatase, lactate dehydrogenase (LDH), glutamic-oxaloacetic transaminase (SGOT), total lipid, cholesterol, triglyceride, alpha-lipoprotein, pre-beta-lipoprotein and beta-lipoprotein) were estimated in 105 pairs of healthy twins of both sexes (57 MZ and 48 DZ) by path analysis. The genotype effect h2 was significant for all traits (P less than 0.001) and its value extended from 0.52 (alpha-lipoprotein) to 0.81 (alkaline phosphatase), whereas environmental effect b2 was significant (P less than 0.05) in only 10 traits of the 17 analyzed, with the maximum value of 0.13 (cholesterol). Correlations between genotypes of paired traits were estimated and, of 136 values, 47 were significant at the 5% levels, thus indicating partial and common genetic mechanisms.

摘要

通过路径分析，对105对健康的双胞胎（57对同卵双胞胎和48对异卵双胞胎）的17种血清生化定量性状（钙、磷、葡萄糖、尿素氮、尿酸、总蛋白、白蛋白、总胆红素、碱性磷酸酶、乳酸脱氢酶（LDH）、谷草转氨酶（SGOT）、总脂质、胆固醇、甘油三酯、α-脂蛋白、前β-脂蛋白和β-脂蛋白）水平的遗传和环境影响进行了估计。基因型效应h2对所有性状均具有显著性（P小于0.001），其值范围从0.52（α-脂蛋白）到0.81（碱性磷酸酶），而环境效应b2仅在17个分析性状中的10个中具有显著性（P小于0.05），最大值为0.13（胆固醇）。对配对性状的基因型之间的相关性进行了估计，在136个值中，47个在5%水平上具有显著性，从而表明存在部分和共同的遗传机制。