Marshall J F, Ungerstedt U
Eur J Pharmacol. 1977 Feb 21;41(4):361-7. doi: 10.1016/0014-2999(77)90256-4.
A new surgical preparation is described with which it is possible to quantify the degree of supersensitivity to dopamine receptor-stimulating agents using the rotational model. One group of rats received a unilateral injection of 6-hydroxydopamine which destroys the dopamine-containing neurons in one hemisphere, followed by a diencephalic electrocoagulation which interrupts both afferents and efferents of the striato-pallidal complex in the opposite hemisphere. Another series of animals received only the unilateral electrocoagulation. When given appomorphine both groups of animals rotated toward the side of the electrocoagulation. However, the 6-hdroxydopamine-treated animals were 10-40 times more sensitive to the behavioral effect of the drug. These results contrast with previous reports in which behavioral sensitivity to apomorphine was increased 2- to 7-fold following partial degeneration of central dopamine neurons of following the chronic adminstration of dopamine synthesis inhibitors of receptor blocking agents. The extent of loss of dopamine appears to be a critical factor in determining the degree of supersensitivity which will develop.
本文描述了一种新的手术制备方法，利用该方法可以通过旋转模型对多巴胺受体激动剂的超敏程度进行量化。一组大鼠接受单侧注射6-羟基多巴胺，该药物会破坏一侧半球中含多巴胺的神经元，随后进行间脑电凝，这会中断对侧半球纹状体-苍白球复合体的传入和传出神经纤维。另一组动物仅接受单侧电凝。当给予阿扑吗啡时，两组动物均向电凝侧旋转。然而，经6-羟基多巴胺处理的动物对该药物的行为效应的敏感性要高10至40倍。这些结果与之前的报告形成对比，在之前的报告中，中枢多巴胺神经元部分变性或长期给予多巴胺合成抑制剂或受体阻断剂后，对阿扑吗啡的行为敏感性增加了2至7倍。多巴胺丧失的程度似乎是决定将产生的超敏程度的关键因素。
