Parkinson C, Beilby J O
J Clin Pathol. 1977 Feb;30(2):113-9. doi: 10.1136/jcp.30.2.113.
One hundred and one testicular tumours previously diagnosed as "teratoma" were examined and 93 of the patients were followed up. These neoplasm were assigned to one of three groups. Those compared exclusively of somatic tissues were the only tumours referred to as teratoma. The second group was exclusively extra embryonic and consisted of either yolk sac or choriocarcinoma. Neoplasms in the third group were called mixed germ cell tumours and incorporated somatic and extra embryonic tissue and occasionally seminoma. The patients with teratomas showed a very low mortality whereas pure yolk sac tumours proved highly malignant. In mixed germ cells tumours the malignant nature of the yolk sac components was maintained even when combined with somatic elements, but when seminoma was also present the survival rate was significantly improved. It would appear the yolk sac tumour tissue occurs more frequently in adult testicular neoplasms than was previously suspected and in mixed germ cell tumours it can be expected to dictate behaviour except when combined with seminoma.
对101例先前诊断为“畸胎瘤”的睾丸肿瘤进行了检查，并对其中93例患者进行了随访。这些肿瘤被分为三组。仅由体细胞组织组成的肿瘤是唯一被称为畸胎瘤的肿瘤。第二组完全是胚外组织，由卵黄囊瘤或绒毛膜癌组成。第三组肿瘤被称为混合性生殖细胞肿瘤，包含体细胞和胚外组织，偶尔还有精原细胞瘤。畸胎瘤患者的死亡率非常低，而单纯的卵黄囊瘤则具有高度恶性。在混合性生殖细胞肿瘤中，即使与体细胞成分结合，卵黄囊成分的恶性性质依然存在，但当同时存在精原细胞瘤时，生存率会显著提高。似乎卵黄囊瘤组织在成人睾丸肿瘤中比以前认为的更常见，并且在混合性生殖细胞肿瘤中，除了与精原细胞瘤结合外，它可能决定肿瘤的行为。
