Jenkins B S, Braimbridge M V
Thorax. 1971 Mar;26(2):206-11. doi: 10.1136/thx.26.2.206.
We describe two patients with Starr-Edwards mitral valve replacements who underwent pregnancy on oral anticoagulants and who were successfully delivered of live babies. The literature on pregnancy with prosthetic heart valves is reviewed. It is suggested that properly controlled oral anticoagulation should be continued until the onset of labour; the anticoagulant effect should then be reversed by an intravenous infusion of fresh-frozen plasma and the patient maintained on intravenous heparin injections six-hourly. Oral anticoagulants should be restarted immediately after delivery and the heparin withdrawn only when their effect has been re-established.
我们描述了两名接受斯塔尔-爱德华兹二尖瓣置换术的患者，她们在口服抗凝剂的情况下怀孕，并成功产下活婴。本文回顾了有关人工心脏瓣膜患者怀孕的文献。建议在分娩开始前持续进行适当控制的口服抗凝治疗；然后通过静脉输注新鲜冷冻血浆来逆转抗凝作用，并让患者每六小时接受一次静脉注射肝素。产后应立即重新开始口服抗凝剂治疗，仅在其抗凝效果重新建立后才停用肝素。
