Rothlin M E
Schweiz Med Wochenschr. 1977 Mar 5;107(9):289-92.
The clinical picture of hypertrophic obstructive cardiomyopathy and the pathogenesis of its hemodynamic alterations are discussed. Dynamic systolic obstruction of the left ventricular outflow-tract, i.e. muscular subaortic stenosis, may or may not be accompanied by hindrance of diastolic filling of the left ventricle and vice versa. It cannot yet be assessed to what extent the reduction of compliance is caused by the pressure load in subaortic stenosis through secondary hypertrophy of the left ventricle. Study of the late course in 28 patients who had undergone surgery reveals that surgery abolishes the pressure gradient in the left ventricular outflow tract and provides year-long relief of symptoms. Complications of obstructive hypertrophic cardiomyopathy, such as mitral incompetence, may be cured by the operation. On the other hand, although progression of the cardiomyopathy is apparently slowed, it can not be abolished by surgical treatment.
本文讨论了肥厚性梗阻性心肌病的临床表现及其血液动力学改变的发病机制。左心室流出道的动态收缩期梗阻,即肌性主动脉瓣下狭窄,可能伴有或不伴有左心室舒张期充盈障碍,反之亦然。目前尚无法评估主动脉瓣下狭窄时因左心室继发性肥厚导致的压力负荷在多大程度上引起顺应性降低。对28例接受手术患者的远期病程研究表明,手术消除了左心室流出道的压力梯度,并使症状长期缓解。梗阻性肥厚性心肌病的并发症,如二尖瓣关闭不全,可通过手术治愈。另一方面,虽然心肌病的进展明显减缓,但手术治疗并不能消除它。