Morin L P, Fitzgerald K M, Zucker I
Science. 1977 Apr 15;196(4287):305-7. doi: 10.1126/science.557840.
Continuous administration of estradiol benzoate by means of subcutaneously implanted capsules shortened the free-running circadian period of locomotor activity of blind hamsters (Mesocricetus auratus) that had had their ovaries removed. Estradiol also advanced the phase of the wheel running of sighted female hamsters without ovaries that were entrained to a photoperiod with 12 hours of light and 12 of darkness. These results, and findings from hamsters undergoing natural estrous cycles, indicate that endogenous estradiol is involved in the regulation of circadian periodicity.
通过皮下植入胶囊持续给予苯甲酸雌二醇，缩短了已摘除卵巢的盲仓鼠（金黄仓鼠）自发活动的昼夜节律周期。雌二醇还使未摘除卵巢、处于12小时光照和12小时黑暗光周期环境中的雌性仓鼠的转轮活动相位提前。这些结果以及处于自然发情周期的仓鼠的研究结果表明，内源性雌二醇参与昼夜节律的调节。
