一些哺乳动物胃窦促胃液素活性的比较研究。
Comparative study of antral gastrin activity in some mammals.
作者信息
Amure B O, Omole A
出版信息
Br J Pharmacol. 1971 Apr;41(4):629-39. doi: 10.1111/j.1476-5381.1971.tb07071.x.
Abstract
- The amounts of crude gastrin extract and the gastrin activities of extracts from antral mucosa of several mammalian species have been determined.2. The yield of crude gastrin powder per gramme wet weight of antral mucosa was greater in goats and rabbits than in cat, dog, man or pig.3. Statistical differences do not appear to exist between the potencies of gastrin from the various species. The potencies of the powders were within the ranges 1.2-1.8 mug porcine gastrin II/mg with the exception of the extract from frozen dog antra (0.8 mug/mg).4. During prolonged freezing of animal antra and consequent thawing before extraction, significant losses in gastrin activity occurred in the dog.5. The amounts of gastrin activity per gramme wet weight of antral mucosa from herbivores (goat, rabbit and cattle) were greater than those from non-herbivores (cat, dog, man and pig).
摘要
已测定了几种哺乳动物胃窦黏膜粗胃泌素提取物的量及其提取物的胃泌素活性。
每克胃窦黏膜湿重的粗胃泌素粉末产量，山羊和兔子比猫、狗、人或猪更高。
不同物种胃泌素的效价之间似乎不存在统计学差异。除冷冻犬胃窦提取物（0.8微克/毫克）外，粉末的效价在1.2 - 1.8微克猪胃泌素II/毫克范围内。
在动物胃窦长时间冷冻并随后在提取前解冻的过程中，犬的胃泌素活性出现了显著损失。
食草动物（山羊、兔子和牛）每克胃窦黏膜湿重的胃泌素活性量大于非食草动物（猫、狗、人及猪）。
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