人干扰素的物理化学性质、诱导细胞与诱导剂之间的关系。
Relationship between the physicochemical nature of human interferon, the cell induced, and the inducing agent.
作者信息
Cesario T C, Schryer P J, Tilles J G
出版信息
Antimicrob Agents Chemother. 1977 Feb;11(2):291-8. doi: 10.1128/AAC.11.2.291.
Abstract
To determine the basis for differences in interferons previously noted by others, we prepared five types of human interferon, namely interferon induced in muscle skin fibroblasts using complexed polyinosinic:polycytidylic acid (IC) and Newcastle disease virus (NDV), and interferon induced in leukocytes using IC, NDV, and phytohemagglutinin. We determined the molecular weight, isoelectric point, inactivation rate at 56 degrees C and structural activity relationships for each interferon. Significant differences between these interferons were found, many of which seem related to the cell induced rather than the inducer. We believe these findings have important pharmacological implications for the use of interferon in man.
摘要
为了确定其他人之前所指出的干扰素差异的基础，我们制备了五种类型的人干扰素，即使用复合多聚肌苷酸：多聚胞苷酸（IC）和新城疫病毒（NDV）在肌肉皮肤成纤维细胞中诱导产生的干扰素，以及使用IC、NDV和植物血凝素在白细胞中诱导产生的干扰素。我们测定了每种干扰素的分子量、等电点、56摄氏度下的失活率以及结构活性关系。发现这些干扰素之间存在显著差异，其中许多差异似乎与诱导细胞而非诱导剂有关。我们认为这些发现对于干扰素在人类中的应用具有重要的药理学意义。
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Nature. 1964 Sep 5;203:1048-50. doi: 10.1038/2031048a0.
2
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