Glick S D, Jerussi T P, Cox R D, Fleisher L N
Arch Int Pharmacodyn Ther. 1977 Feb;225(2):303-7.
Normal rats were tested for rotation (circling behavior) following d-amphetamine (1.0 mg/kg) and, a week later, following apomorphine (10.0 mg/kg). In most rats, d-amphetamine and apomorphine elicited rotation in opposite directions whereas, in some rats, the two drugs elicited rotation in the same direction. Subsequently, alpha-methyl-p-tyrosine was found to antagonize the rotatory effect of apomorphine in the latter but not in the former rats. The results suggest that apomorphine has both pre- and post-synaptic actions and that relative sensitivity to these actions varies among rats.
对正常大鼠注射d-苯丙胺（1.0毫克/千克）后测试其旋转（转圈行为），一周后再注射阿扑吗啡（10.0毫克/千克）进行测试。在大多数大鼠中，d-苯丙胺和阿扑吗啡引发的旋转方向相反，而在一些大鼠中，这两种药物引发的旋转方向相同。随后发现，α-甲基-对-酪氨酸可拮抗阿扑吗啡对后一组大鼠的旋转作用，但对前一组大鼠无效。结果表明，阿扑吗啡具有突触前和突触后作用，并且大鼠对这些作用的相对敏感性各不相同。
