Jerussi T P, Glick S D
Psychopharmacologia. 1975;40(4):329-34. doi: 10.1007/BF00421471.
Apomorphine (i.p.) induced rotational behavior (i.e. circling) in normal unoperated rats. This rotation increased with increasing dose up to 10.0 mg/kg, after which the dose-response curve appeared to plateau. Although there was large variability among rats, rotation for each rat was consistent in both direction and magnitude from week to week. Rotation was not antagonized by alpha-methyl-para-tyrosine. When rats with unilateral lesions of the caudate nucleus were tested with apomorphine, postoperative rotation was significantly influenced by the direction of preoperative rotation; rats rotated more postoperatively if the lesion was made ipsilateral rather than contralateral to their preoperative direction of rotation. These results suggest that there is a bilateral asymmetry of dopaminergic receptors in the nigro-striatal pathways of normal rats.
阿扑吗啡（腹腔注射）可诱导正常未手术大鼠出现旋转行为（即转圈）。这种旋转随着剂量增加至10.0 mg/kg而增强，此后剂量-反应曲线似乎趋于平稳。尽管大鼠之间存在很大变异性，但每只大鼠每周的旋转方向和幅度都是一致的。α-甲基-对-酪氨酸不会拮抗旋转。当用阿扑吗啡对尾状核单侧损伤的大鼠进行测试时，术后旋转明显受术前旋转方向的影响；如果损伤是在术前旋转方向的同侧而非对侧造成的，大鼠术后旋转更多。这些结果表明，正常大鼠黑质-纹状体通路中多巴胺能受体存在双侧不对称性。
