Petrov R V, Panteleev E I, Moshiashvili I Ia, Shemanova G F, Vlasova E V
Biull Eksp Biol Med. 1977 Feb;83(2):198-200.
Mice belonging to a number of inbred strains were immunized intradermally with Cl. oedematiens alpha-toxoid. The immunization was repeated 30 days later. On the 20th and the 30th days after the first injection and on the 10th day after the second one the antibody level against the toxoid was determined in the blood of mice by the passive hemagglutination test. The maximum response to the primary immunization was observed in the mice of the C3H strain, and the minimum one--in mice of the DBA/2 strain; the difference was more than 30-fold. The rest of the strains used in the test (A,CBA, BALB/c, AKR, CC57BR) displayed an intermediate level of the immune response. The differences reduced after the repeated immunization. The immune response to this antigen in mice is supposed to be genetically controlled.
用水肿杆菌α类毒素对多个近交系小鼠进行皮内免疫。30天后重复免疫。在首次注射后的第20天和第30天以及第二次注射后的第10天，通过被动血凝试验测定小鼠血液中针对类毒素的抗体水平。在C3H品系小鼠中观察到对初次免疫的最大反应，而在DBA/2品系小鼠中反应最小；差异超过30倍。试验中使用的其他品系（A、CBA、BALB/c、AKR、CC57BR）表现出中等水平的免疫反应。重复免疫后差异减小。推测小鼠对该抗原的免疫反应受遗传控制。
