Mizuno M, Suzuki K, Tomita T, Kondo K
Jikken Dobutsu. 1977 Jan;26(1):43-9. doi: 10.1538/expanim1957.26.1_43.
In order to check genetic purity of inbred strains of mice, we surveyed five biochemical variants in certain 69 strains, some of which had established from Japanese fancy mice. The loci examined were Hemoglobin beta-chain, Malic enzyme (supernatant form), Isocitrate dehydrogenase (supernatant form), Serum esterase-1, and Serum esterase-2. These loci were all in homozygous states as far as examined, however some subline divergences were found in a few strains, that is to say, sublines were found to be fixed with different alleles as some loci, Important of biochemical marker genes to check genetic purity of strains and several derived problems are mentioned.
为检测近交系小鼠的遗传纯度，我们调查了69个品系中的5种生化变异体，其中一些品系源自日本观赏小鼠。检测的基因座包括血红蛋白β链、苹果酸酶（上清液形式）、异柠檬酸脱氢酶（上清液形式）、血清酯酶-1和血清酯酶-2。就检测情况而言，这些基因座均处于纯合状态，然而在少数品系中发现了一些亚系差异，也就是说，在某些基因座上，亚系被发现固定有不同的等位基因。文中提到了生化标记基因对检测品系遗传纯度的重要性以及一些衍生问题。
