Dabelsteen E, Roed-Petersen B, Smith C J, Pindborg J J
Br J Cancer. 1971 Mar;25(1):21-4. doi: 10.1038/bjc.1971.3.
Two hundred and ninety-nine oral leukoplakias were examined by exfoliative cytology; 83 of these lesions were biopsied because of clinical or previous histological features. Epithelial atypia was found in 16 of these biopsies, exfoliative cytology detecting epithelial atypia in only 6 of these cases. Thus exfoliative cytology used alone would have led to a false negative diagnosis in 10 out of 16 (62%) of the cases with epithelial atypia verified by histology. In addition, in no instance was exfoliative cytology responsible for the detection of an epithelial atypia that had been overlooked by consideration of clinical or previous histological features. Exfoliative cytology was successful in the detection of atypia only in those cases in which the surface of the lesion was either ulcerated or not keratinized; all keratinized lesions with atypia yielded negative cytology. The results of this study lead to the conclusion that exfoliative cytology is not to be recommended as a routine diagnostic or screening procedure for the detection of possibly pre-malignant features in oral leukoplakias.
对299例口腔白斑进行了脱落细胞学检查；其中83例病变因临床或既往组织学特征而进行了活检。在这些活检病例中，有16例发现上皮异型性，而脱落细胞学仅在其中6例中检测到上皮异型性。因此，单独使用脱落细胞学检查会导致在经组织学证实的16例上皮异型性病例中有10例（62%）出现假阴性诊断。此外，脱落细胞学从未检测出临床或既往组织学检查遗漏的上皮异型性。脱落细胞学仅在病变表面溃疡或未角化的病例中成功检测出异型性；所有伴有异型性的角化病变细胞学检查均为阴性。本研究结果得出结论，不建议将脱落细胞学作为检测口腔白斑可能的癌前特征的常规诊断或筛查方法。
