Lubin A H, Garry P J, Owen G M
Science. 1971 Jul 9;173(3992):161-4. doi: 10.1126/science.173.3992.161.
Accumulating knowledge of polymorphic enzyme systems poses intriguing possibilities of anthropologic genetics. Development of an automated procedure for determination of heterozygosity or homozygosity of the atypical plasma cholinesterase allele (E(1)(a)) permitted screening of 2317 individuals during a national Preschool Nutrition Survey and several smaller population studies. Frequencies of the allele (E(1)(a)) closely parallel those previously reported. Caucasians manifested a heterozygote male preponderance of 1.85: 1.
对多态酶系统知识的不断积累为人类遗传学带来了有趣的可能性。一种用于测定非典型血浆胆碱酯酶等位基因（E(1)(a)）杂合性或纯合性的自动化程序的开发，使得在一项全国性学龄前儿童营养调查以及几项较小规模的人群研究中对2317人进行了筛查。等位基因（E(1)(a)）的频率与先前报道的频率非常接近。高加索人群中杂合子男性占比为1.85:1。
