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寒冷诱发的甲状腺功能亢进的心脏效应及心肌梗死发病率的季节性变化

Cardiac effects of cold-induced hyperthyroidism and the seasonal variation in incidence of myocardial infarction.

作者信息

Harland W A, Orr J S, Dunnigan M G, Fyfe T

出版信息

Br J Exp Pathol. 1971 Apr;52(2):147-51.

Abstract

Cold exposure was found to increase the size of the rat's heart and the resting heart rate. Following administration of atropine and propranolol, the “intrinsic heart rate” was also elevated. The thyroxine content of the heart was increased on exposure to cold. It is suggested that this evidence of increased heart work and irritability might explain the higher death rate from myocardial infarction in the winter months.

摘要

研究发现,寒冷暴露会使大鼠心脏增大,静息心率加快。给予阿托品和普萘洛尔后,“固有心率”也会升高。暴露于寒冷环境时,心脏的甲状腺素含量会增加。有人认为,这种心脏工作增加和易激惹性增强的证据可能解释了冬季心肌梗死死亡率较高的原因。

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Endocrinological aspects of exposure to high environmental temperatures.
Physiol Rev. 1968 Oct;48(4):785-839. doi: 10.1152/physrev.1968.48.4.785.
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A metabolic cause for arrhythmias during acute myocardial hypoxia.
Lancet. 1970 Apr 18;1(7651):813-5. doi: 10.1016/s0140-6736(70)92412-8.
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Cold weather and myocardial infarction.寒冷天气与心肌梗死
Lancet. 1970 Feb 7;1(7641):291-6. doi: 10.1016/s0140-6736(70)90651-3.
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The role of the thyroid in the control of heart-rate.甲状腺在控制心率方面的作用。
Lancet. 1968 May 11;1(7550):998-1000. doi: 10.1016/s0140-6736(68)91109-4.

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