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1
Cardiac effects of cold-induced hyperthyroidism and the seasonal variation in incidence of myocardial infarction.寒冷诱发的甲状腺功能亢进的心脏效应及心肌梗死发病率的季节性变化
Br J Exp Pathol. 1971 Apr;52(2):147-51.
2
Role of the autonomic nervous system in the resting tachycardia of experimental hyperthyroidism.自主神经系统在实验性甲状腺功能亢进静息性心动过速中的作用。
J Pharmacol Exp Ther. 1967 Oct;158(1):55-65.
3
Myocardial infarction and weather.心肌梗死与天气
Ann Clin Res. 1977 Aug;9(4):222-32.
4
Myocardial contractility, and the effects of beta-adrenergic blockade in hypothyroidism and hyperthyroidism.
Clin Sci. 1968 Jun;34(3):485-95.
5
[Effects of protocatechuic acid and propranolol on myocardial metabolism and infarct size in dogs with acute myocardial infarction].
Zhongguo Yao Li Xue Bao. 1988 Jan;9(1):27-30.
6
Propranolol and experimental myocardial infarction: substrate effects.
Postgrad Med J. 1976;52 Suppl 4:124-32.
7
Excessive thyroxine enhances susceptibility to apoptosis and decreases contractility of cardiomyocytes.甲状腺素过量会增强心肌细胞对细胞凋亡的敏感性，并降低其收缩力。
Mol Cell Endocrinol. 2010 May 14;320(1-2):67-75. doi: 10.1016/j.mce.2010.01.031. Epub 2010 Feb 1.
8
[Coronary patients in change of seasons. How heat and cold affect myocardial infarct].[冠心病患者的季节变化。炎热与寒冷如何影响心肌梗死]
MMW Fortschr Med. 2003 Sep 4;145(35-36):26-7.
9
Regional changes in myocyte size and number in propranolol-treated hyperthyroid rats.普萘洛尔治疗的甲状腺功能亢进大鼠心肌细胞大小和数量的区域变化。
Lab Invest. 1987 Dec;57(6):708-13.
10
Failure of propranolol to prevent chronic hyperthyroid induced cardiac hypertrophy and multifocal cellular necrosis in the rat.普萘洛尔未能预防大鼠慢性甲状腺功能亢进诱导的心脏肥大和多灶性细胞坏死。
Can J Cardiol. 1985 Sep-Oct;1(5):340-5.

本文引用的文献

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Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium.甲状腺状态对心肌固有收缩特性和能量储备的影响。
J Clin Invest. 1967 Oct;46(10):1669-82. doi: 10.1172/JCI105658.
2
Cardiac output and organ blood flow in warm- and cold-acclimated rats exposed to cold.暴露于寒冷环境中的暖适应和冷适应大鼠的心输出量及器官血流量
Can J Physiol Pharmacol. 1968 Jul;46(4):653-9. doi: 10.1139/y68-096.
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Occupancy principle for radioactive tracers in steady-state biological systems.稳态生物系统中放射性示踪剂的占据原理。
Science. 1968 Oct 4;162(3849):138-9. doi: 10.1126/science.162.3849.138.
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Effect of the thyroid state on myocardial contractility and ventricular ejection rate in man.甲状腺状态对人体心肌收缩力和心室射血率的影响。
Circulation. 1968 Aug;38(2):229-39. doi: 10.1161/01.cir.38.2.229.
5
Effects of acute myocardial infarction and of noradrenaline infusion on fatty acid composition of serum lipids.急性心肌梗死及去甲肾上腺素输注对血脂脂肪酸组成的影响。
Atherosclerosis. 1970 Jan-Feb;11(1):157-70. doi: 10.1016/0021-9150(70)90013-4.
6
A model of thyroxine metabolism based on the effects of environmental temperature.基于环境温度影响的甲状腺素代谢模型。
J Physiol. 1969 Feb;200(2):297-310. doi: 10.1113/jphysiol.1969.sp008694.
7
Endocrinological aspects of exposure to high environmental temperatures.
Physiol Rev. 1968 Oct;48(4):785-839. doi: 10.1152/physrev.1968.48.4.785.
8
A metabolic cause for arrhythmias during acute myocardial hypoxia.
Lancet. 1970 Apr 18;1(7651):813-5. doi: 10.1016/s0140-6736(70)92412-8.
9
Cold weather and myocardial infarction.寒冷天气与心肌梗死
Lancet. 1970 Feb 7;1(7641):291-6. doi: 10.1016/s0140-6736(70)90651-3.
10
The role of the thyroid in the control of heart-rate.甲状腺在控制心率方面的作用。
Lancet. 1968 May 11;1(7550):998-1000. doi: 10.1016/s0140-6736(68)91109-4.

寒冷诱发的甲状腺功能亢进的心脏效应及心肌梗死发病率的季节性变化

Cardiac effects of cold-induced hyperthyroidism and the seasonal variation in incidence of myocardial infarction.

作者信息

Harland W A, Orr J S, Dunnigan M G, Fyfe T

出版信息

Br J Exp Pathol. 1971 Apr;52(2):147-51.

PMID:5582074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2072253/
Abstract

Cold exposure was found to increase the size of the rat's heart and the resting heart rate. Following administration of atropine and propranolol, the “intrinsic heart rate” was also elevated. The thyroxine content of the heart was increased on exposure to cold. It is suggested that this evidence of increased heart work and irritability might explain the higher death rate from myocardial infarction in the winter months.

摘要

研究发现，寒冷暴露会使大鼠心脏增大，静息心率加快。给予阿托品和普萘洛尔后，“固有心率”也会升高。暴露于寒冷环境时，心脏的甲状腺素含量会增加。有人认为，这种心脏工作增加和易激惹性增强的证据可能解释了冬季心肌梗死死亡率较高的原因。