Trevoux R
J Gynecol Obstet Biol Reprod (Paris). 1977 Jan;6(1):99-105.
The experimental work of Robert on the action of the unsaponifiable fractions of the avocado pear and soya bean on inflammatory granulomata of the rat gives rise to the supposition that these have a selective action on inflamed connective tissue by a process of katabolism of collagen through proteolytic enzymes. We have used this anti-inflammatory and collagenolytic action in gynaecology, with favourable results particularly in post-inflammatory and post-infective conditions as well as scarring in the pelvis. The decongesting action of the unsaponifiables of the avocado pear and the soya bean seems also to have a role to play in cellular tissue reactions in the pelvis after cobalt therapy, and in recent retractile scars and in breast inflammations, as well as to prevent scar reactions after operations. Since treatment has to be for a long time and well tolerated, the blood lipids should be estimated as a safety measure. If this is done the unsaponifiables seem to have a place in the treatment of inflammatory conditions in gynaecology.
罗伯特关于鳄梨和大豆不皂化物对大鼠炎性肉芽肿作用的实验研究表明,这些物质可能通过蛋白水解酶对胶原蛋白进行分解代谢,从而对发炎的结缔组织产生选择性作用。我们已将这种抗炎和胶原分解作用应用于妇科,尤其在炎症后和感染后状况以及盆腔瘢痕形成方面取得了良好效果。鳄梨和大豆不皂化物的消肿作用似乎在钴治疗后盆腔的细胞组织反应、近期的收缩性瘢痕和乳腺炎症中也发挥着作用,还能预防术后瘢痕反应。由于治疗必须持续较长时间且耐受性良好,应检测血脂作为安全措施。若如此,不皂化物在妇科炎症性疾病的治疗中似乎有一席之地。