Hope D B, Horncastle K C, Aplin R T
Biochem J. 1967 Nov;105(2):663-7. doi: 10.1042/bj1050663.
The l-amino acid oxidase of Mytilus edulis has been used to oxidize l-lysine on a large scale in the presence of catalase. The alpha-oxo acid derived from lysine cyclizes to a Schiff base, which readily dimerizes. The dimer undergoes spontaneous dehydration and decarboxylation to form 1,2,3,4,5,6,7,8-octahydropyrido[3,2-a]-indolizin-10(4bH)-one. This structure was established by a study of its molecular weight and infrared, nuclear-magnetic-resonance and mass spectra.
紫贻贝的L-氨基酸氧化酶已被用于在过氧化氢酶存在的情况下大规模氧化L-赖氨酸。赖氨酸衍生的α-氧代酸环化形成席夫碱，该席夫碱很容易二聚。二聚体发生自发脱水和脱羧反应，形成1,2,3,4,5,6,7,8-八氢吡啶并[3,2-a]-中氮茚-10(4bH)-酮。通过对其分子量以及红外光谱、核磁共振光谱和质谱的研究确定了该结构。
