Mueller S M, Bell W, Cornell S, de Hamsher K, Dolan K
Neurology. 1977 May;27(5):430-4. doi: 10.1212/wnl.27.5.430.
Nine achondroplastic dwafts were studied with computerized tomography, skull and cervical spine films, and psychometric testing. All had large ventricles that ranged from the top limits of normal to severe hydrocephalus. Three had enlarged cortical sulci. Skull and cervical spine films were typical for achondroplasia, but in addition significant asymmetry of the petrous ridge was noted. Psychometric testing disclosed generally average intelligence quotients which fell below the expected performance level in each case. These findings may be explained on the basis of the abnormal endochondral bone formation found in achondroplasia.
对9名软骨发育不全侏儒进行了计算机断层扫描、头颅和颈椎X光片检查以及心理测试。所有人都有大的脑室，范围从正常上限到严重脑积水。3人有脑沟增宽。头颅和颈椎X光片表现为典型的软骨发育不全，但此外还发现岩骨嵴明显不对称。心理测试显示智商总体处于平均水平，但在每种情况下都低于预期表现水平。这些发现可以基于软骨发育不全中发现的异常软骨内骨形成来解释。
