Glasser L, Payne C, Corrigan J J
Neurology. 1977 May;27(5):448-59. doi: 10.1212/wnl.27.5.448.
This is a case study of a patient with the clinical diagnosis of meningoencephalitis. It demonstrates the in vivo development of plasma cells in the central nervous system. All the stages of in vitro mitogen-induced lymphocyte transformation previously described by light and electron microscopy are recapitulated in this analysis of cerebrospinal fluid. It is postulated that this represents a local humoral immune reaction in the central nervous system and provides morphologic support for the concept that the gamma globulin in cerebrospinal fluid is produced locally in part, in addition to its origin from the plasma proteins.
这是一例临床诊断为脑膜脑炎患者的病例研究。它展示了中枢神经系统中浆细胞的体内发育情况。先前通过光学和电子显微镜描述的体外有丝分裂原诱导淋巴细胞转化的所有阶段，在本次脑脊液分析中均有重现。据推测，这代表了中枢神经系统中的局部体液免疫反应，并为脑脊液中的γ球蛋白除了来源于血浆蛋白外，部分是在局部产生这一概念提供了形态学支持。
