Schain R J, Ward J W, Guthrie D
Neurology. 1977 May;27(5):476-80. doi: 10.1212/wnl.27.5.476.
Forty-five children with major motor or psychomotor seizure disorders were treated with carbamazepine in place of sedative anticonvulsants (phenobarbital, primidone) because of chronic behavioral difficulties. A batter of measures believed to reflect attentional and perceptual abilities was administered initially and repeated 4 to 6 months later following the drug crossover. At the conclusion of the study, 37 of the 45 children were judged to be drug "successes"; that is, general alertness and attentiveness were improved, while seizures were adequately controlled. This study indicates that therapeutic regimens of carbamazepine are less likely to interfere with mental functions in children than are equivalent doses of sedative anticonvulsants.
由于存在慢性行为问题，45名患有严重运动性或精神运动性癫痫发作障碍的儿童接受了卡马西平治疗，以替代镇静抗惊厥药（苯巴比妥、扑米酮）。在药物交叉使用前，首先进行了一系列被认为能反映注意力和感知能力的测试，并在4至6个月后重复进行。研究结束时，45名儿童中有37名被判定为药物“成功使用者”；也就是说，总体警觉性和注意力得到了改善，同时癫痫发作也得到了充分控制。这项研究表明，与等效剂量的镇静抗惊厥药相比，卡马西平的治疗方案对儿童心理功能的干扰可能性较小。
