丙戊酸钠和卡马西平对癫痫的心理影响。
Psychological effects of sodium valproate and carbamazepine in epilepsy.
作者信息
Stores G, Williams P L, Styles E, Zaiwalla Z
机构信息
University of Oxford Section of Child and Adolescent Psychiatry, Headington.
出版信息
Arch Dis Child. 1992 Nov;67(11):1330-7. doi: 10.1136/adc.67.11.1330.
Information from standardised tests of intelligence, school attainments, attention, memory and visuomotor function, together with parent and teacher questionnaire information about various aspects of behaviour, was obtained for 63 schoolchildren with newly diagnosed epilepsy before treatment with sodium valproate or carbamazepine, and again at intervals for a total period of 12 months. The same information was collected on 47 matched controls. The children with epilepsy represented those under non-specialised paediatric care. The result showed that both drugs were effective in most cases at modest dosage without causing notable psychological effects 12 months into treatment. Modest and temporary adverse cognitive effects seen earlier in treatment could have been the result of uncontrolled seizure discharge. Improved function was the same in children with epilepsy and controls. Some psychological abnormalities in the children with epilepsy were evident before treatment suggesting early unwanted effects of the epileptic process itself.
在63名新诊断为癫痫且尚未接受丙戊酸钠或卡马西平治疗的学龄儿童中，获取了来自智力标准化测试、学业成绩、注意力、记忆力和视觉运动功能的信息，以及家长和教师关于行为各方面的问卷调查信息；治疗期间每隔一段时间再次收集这些信息，为期共12个月。在47名匹配的对照组中收集了相同的信息。患有癫痫的儿童均接受非专科儿科护理。结果显示，在治疗12个月时，两种药物在大多数情况下以适度剂量使用均有效，且未引起明显的心理影响。治疗早期出现的适度且短暂的不良认知影响可能是癫痫发作未得到控制的结果。癫痫儿童和对照组儿童的功能改善情况相同。癫痫儿童在治疗前就存在一些心理异常，这表明癫痫过程本身早期就产生了不良影响。
Zotero 插件