一种新的杂合血红蛋白：斯特鲁米察/贝尔格莱德血红蛋白出现在一个拥有四种血红蛋白的个体中。
A new hybrid haemoglobin: haemoglobin Strumica/Beograd occurring in an individual with four haemoglobins.
作者信息
Wilkinson T, Carrell R W, Brennan S, Gough P, Robin H, Kronenberg H
出版信息
Pathology. 1977 Jan;9(1):27-37. doi: 10.3109/00313027709085235.
An investigation of the cord blood from full term twin infants revealed an additional haemoglobin F component due to an abnormal alpha chain. The father of the twins, whose blood picture was normal, was shown to have normal alpha and beta polypeptide chains together with variant alpha and beta polypeptide chains. Electrophoresis showed that he had four major haemoglobin components. Separation of the haemoglobin fractions by column chromatography, globin preparation, chain separation, tryptic and chymotryptic digestion and peptide map preparation led to the identification of haemaglobin A, haemoglobin Strumica (alpha2 112His leads to Arg beta2), haemoglobin D Beograd (alpha2beta2 121 Glu leads to Val) and a hybrid haemoglobin Strumica D/Beograd (alpha2 112His leads to Argbeta2 121Glu leads to Val).
对足月双胞胎婴儿的脐带血进行的一项调查显示，由于异常的α链，存在一种额外的血红蛋白F成分。双胞胎的父亲血液检查结果正常，其α和β多肽链正常，但同时也存在变异的α和β多肽链。电泳显示他有四种主要的血红蛋白成分。通过柱色谱法分离血红蛋白组分、制备珠蛋白、分离链、胰蛋白酶和糜蛋白酶消化以及制备肽图谱，鉴定出了血红蛋白A、斯特鲁米察血红蛋白（α2 112位组氨酸突变为精氨酸β2）、贝尔格莱德血红蛋白D（α2β2 121位谷氨酸突变为缬氨酸）以及一种杂合的斯特鲁米察D/贝尔格莱德血红蛋白（α2 112位组氨酸突变为精氨酸β2 121位谷氨酸突变为缬氨酸）。
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