Vyskocil F, Gutmann E
Pflugers Arch. 1977 Mar 11;368(1-2):105-9. doi: 10.1007/BF01063461.
Electrical and contractile properties of the levator ani muscle were studied in normal rats, in castrated rats and in castrated rats treated with testosterone. 2. No significant changes in the frequency of miniature end-plate potentials were found 6 months after castration. The frequency increased already 6 h after testosterone treatment; an increase of about 100% was observed after 7 days of testosterone treatment. 3. Castration led to a 2-fold increase of the input resistance of the muscle fibres. After 7 days of testosterone treatment the input resistance was only slightly higher than normal. 4. The weight of the muscle was decreased to 18% of the control value after 6 months castration. It increased to 46% after 7 days of testosterone treatment. 5. The muscles of castrated animals revealed a prolongation of contraction time and marked changes in maximal rate of tension development and half relaxation time. Partial recovery of these parameters was found after 7 days of testosterone treatment. 6. Long-term castration did not induce any denervation-like changes of action potential parameters, and no tetrodotoxin resistance was found in spite of marked muscle atrophy.
研究了正常大鼠、去势大鼠以及用睾酮治疗的去势大鼠提肛肌的电特性和收缩特性。2. 去势6个月后，微小终板电位频率未发现显著变化。睾酮治疗6小时后频率即开始增加；睾酮治疗7天后观察到频率增加约100%。3. 去势导致肌纤维输入电阻增加2倍。睾酮治疗7天后，输入电阻仅略高于正常水平。4. 去势6个月后，肌肉重量降至对照值的18%。睾酮治疗7天后，肌肉重量增加至46%。5. 去势动物的肌肉收缩时间延长，张力发展最大速率和半松弛时间有明显变化。睾酮治疗7天后，这些参数部分恢复。6. 长期去势未引起动作电位参数的任何去神经样变化，尽管肌肉明显萎缩，但未发现对河豚毒素有抗性。
