Notelovitz M, James S
Horm Metab Res. 1977 Mar;9(2):105-8. doi: 10.1055/s-0028-1093554.
A study was undertaken in Natal Indians to determine the insulin secretory response and the comparative degree of free fatty acidaemia in normal and insulin-independent diabetic pregnant women. The fasting plasma FFA and glucose levels were found to be substantially greater in the diabetic subjects. The pattern of plasma FFA and glucose response to exogenous insulin was similar in both groups. Endogenous insulin produced a similar FFA response, but a markedly obtunded blood sugar response occurred among the diabetics despite adequate plasma insulin levels. The significance of the differential effect of endogenous insulin on FFA and glucose metabolism in pregnant insulin-independent Natal Indian diabetics is discussed.
在纳塔尔印第安人中开展了一项研究，以确定正常和非胰岛素依赖型糖尿病孕妇的胰岛素分泌反应以及游离脂肪酸血症的比较程度。结果发现，糖尿病受试者的空腹血浆游离脂肪酸（FFA）和葡萄糖水平显著更高。两组对外源性胰岛素的血浆FFA和葡萄糖反应模式相似。内源性胰岛素产生了相似的FFA反应，但尽管血浆胰岛素水平充足，糖尿病患者中仍出现了明显迟钝的血糖反应。文中讨论了内源性胰岛素对纳塔尔印第安非胰岛素依赖型糖尿病孕妇的FFA和葡萄糖代谢的不同作用的意义。
