Gillmer M D, Beard R W, Oakley N W, Brooke F M, Elphick M C, Hull D
Br Med J. 1977 Sep 10;2(6088):670-3. doi: 10.1136/bmj.2.6088.670.
Diurnal plasma free fatty acid (FFA) and glucose concentrations were measured in 23 normal women, 13 chemical diabetics, and 11 insulin-dependent diabetics in late pregnancy. The mean diurnal FFA value was lowest in the insulin-requiring diabetics and highest in the chemical diabetics. Although no association was found between percentile birthweight and maternal mean fasting or diurnal FFA, there was a positive correlation between percentile birthweight and both mean maternal fasting plasma glucose and mean diurnal glucose in normal and chemical diabetic women. These observations support the view that glucose is the major substrate used by the fetus, but birthweight may be influenced more by the total substrate crossing the placenta than by maternal levels of either glucose or FFA alone.
对23名正常孕妇、13名化学性糖尿病孕妇和11名妊娠晚期胰岛素依赖型糖尿病孕妇进行了日间血浆游离脂肪酸（FFA）和葡萄糖浓度测定。胰岛素依赖型糖尿病孕妇的日间FFA均值最低，化学性糖尿病孕妇的最高。尽管出生体重百分位数与母亲平均空腹或日间FFA之间未发现关联，但在正常孕妇和化学性糖尿病孕妇中，出生体重百分位数与母亲平均空腹血糖及平均日间血糖均呈正相关。这些观察结果支持以下观点：葡萄糖是胎儿使用的主要底物，但出生体重可能更多地受穿越胎盘的总底物影响，而非仅受母亲葡萄糖或FFA水平影响。
