通过圆二色性测量揭示的汞（II）离子与DNA的相互作用。
Interactions of Hg(II) ions with DNA as revealed by CD measurements.
作者信息
Walter A, Luck G
出版信息
Nucleic Acids Res. 1977 Mar;4(3):539-50. doi: 10.1093/nar/4.3.539.
Abstract
The circular dichroism spectra of Hg(II) complexes with native calf thymus DNA, chemically methylated Streptomyces chrysomallus DNA and with Ag(I)-DNA complexes were measured in the region of 220 - 340 nm. As a main result a conversion of the conservative CD spectrum of DNA to a distinct nonconservative type of CD spectrum for the complexes occurs with increasing Hg(II) concentration. The CD spectra of the Hg(II) complexes as well as some additional arguments strongly support the idea, that DNA in the complex undergoes a structural transition to a more condensed state with 4 -like character.
摘要
在220 - 340纳米区域测量了汞（II）与天然小牛胸腺DNA、化学甲基化的金色链霉菌DNA以及银（I）-DNA复合物的圆二色光谱。主要结果是，随着汞（II）浓度的增加，DNA保守的圆二色光谱转变为复合物独特的非保守型圆二色光谱。汞（II）复合物的圆二色光谱以及一些其他论据有力地支持了这样一种观点，即复合物中的DNA经历了向具有类似Z型特征的更浓缩状态的结构转变。
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