Jackson P S, Cooper M J
Vet Rec. 1977 Apr 23;100(17):361-3. doi: 10.1136/vr.100.17.361.
Misalliance and mummification are two indications for treatment with cloprostenol. Of 56 animals mated accidentally that were treated with 0-5 mg cloprostenol, 12 were more than 150 days pregnant and of those, nine required more than one treatment. The animals treated early in pregnancy aborted promptly and completely whereas two, considered to be 200 days pregnant at the first treatment, failed to respond at all. There were no reports of retained fetal membranes or any adverse side effects. Eight cases of fetal mummification were also submitted for treatment. All aborted within three to five days, the fetus being removed manually per vaginam in each case. Serial blood progesterone assays indicated that successful treatment was associated with leutolysis in all cases. It was concluded that cloprostenol may successfully be used for the treatment of misalliance and mummification of the fetus.
配种不当和胎儿干尸化是使用氯前列醇治疗的两种指征。在56只意外配种的动物中,用0.5毫克氯前列醇进行治疗,其中12只怀孕超过150天,在这些动物中,9只需要不止一次治疗。在妊娠早期接受治疗的动物迅速且完全流产,而有两只在首次治疗时被认为已怀孕200天,却完全没有反应。没有关于胎膜残留或任何不良副作用的报告。还有8例胎儿干尸化病例也接受了治疗。所有病例均在三至五天内流产,每例均通过阴道手动取出胎儿。连续的血液孕酮检测表明,在所有病例中,成功的治疗都与黄体溶解有关。得出的结论是,氯前列醇可成功用于治疗配种不当和胎儿干尸化。