Eckel R H, Crowell E B, Waterhouse B E, Bozdech M J
Arch Intern Med. 1977 Jun;137(6):735-7. doi: 10.1001/archinte.137.6.735.
Two patients with thrombotic thrombocytopenic purpura were seen. Aspirin, dipyridamole, and sulfinpyrazone were administered to patient 1 after splenectomy, and administration of high-dose prednisone and methylprednisolone failed to induce remission. The platelet count rose, but the patient had a relapse when the dipyridamole dose was tapered. This condition responded to an increase of the drug, and the patient obtained a long-lasting remission. A splenectomy was not performed on patient 2, and all three platelet-inhibiting drugs, together with prednisone, were given. This resulted in a prompt remission that has been sustained for 29 weeks. Morphologic changes in the peripheral blood smear remained for several weeks after other features of the disease had resolved. Thus, in both cases, platelet-inhibiting drugs appeared to induce a remission.
我们诊治了两名血栓性血小板减少性紫癜患者。患者1在脾切除术后接受了阿司匹林、双嘧达莫和苯磺唑酮治疗，大剂量泼尼松和甲泼尼龙治疗未能诱导缓解。血小板计数有所上升，但当双嘧达莫剂量逐渐减小时患者病情复发。增加该药物剂量后病情得到缓解，患者获得了持久缓解。患者2未进行脾切除术，给予了所有三种血小板抑制药物以及泼尼松。这导致迅速缓解，且已持续29周。在疾病的其他特征消退后，外周血涂片的形态学改变仍持续了数周。因此，在这两个病例中，血小板抑制药物似乎都诱导了缓解。
