Epstein J A
Fertil Steril. 1977 Jul;28(7):741-5. doi: 10.1016/s0015-0282(16)42676-2.
This study of the effects of long-term clomiphene administration on semen analyses of oligospermic infertile males once again points to the potential therapeutic efficacy of clomiphene in certain subjects. Although the group of 16 subjects was small, all were men with long-standing infertility that had been refractory to previous treatments such as exogenous injections of human chorionic gonadotropin and varicocelectomy; 10 of the 16 men (62.5%) showed improvement in sperm counts within 2 to 5 months of starting clomiphene. Sperm motility improved moderately when counts improved; no effects on sperm morphology were noted. Of the 10 men classified as semen responders to clomiphene, 5 (50%) were successful in impregnating their wives within 2 to 8 months of starting treatment. These results approach the therapeutic efficacy seen with clomiphene in appropriately selected females with ovulatory disturbances. We have been unable to predict or characterize the patient who might be expected to show a semen response to clomiphene by history, physical examination response to previous treatment, or changes in blood testosterone levels while taking clomiphene.
这项关于长期服用克罗米芬对少精子症不育男性精液分析影响的研究再次表明，克罗米芬对某些患者具有潜在的治疗效果。尽管16名受试者的样本量较小，但他们均为长期不育且对以往治疗（如外源性注射人绒毛膜促性腺激素和精索静脉曲张切除术）无效的男性；16名男性中有10名（62.5%）在开始服用克罗米芬后的2至5个月内精子数量有所改善。当精子数量增加时，精子活力有适度提高；未观察到对精子形态的影响。在被归类为对克罗米芬有精液反应的10名男性中，有5名（50%）在开始治疗后的2至8个月内成功使妻子受孕。这些结果接近克罗米芬在适当选择的排卵障碍女性中所观察到的治疗效果。我们无法通过病史、体格检查、对既往治疗的反应或服用克罗米芬期间血液睾酮水平的变化来预测或描述可能对克罗米芬有精液反应的患者。
