Inoue S, Dionne G P
Am J Pathol. 1977 Aug;88(2):345-54.
Tonofilaments in the cells of squamous cell carcinoma of human bronchial epithelium were observed and compared to those in normal bronchial epithelium in 2 patients. In the normal tissue, only small numbers of tonofilaments were observed, and these were found only in the basal cells of the epithelium. In the tumor cells, the quantity of filaments increased considerably. They appeared in the cytoplasm both as branching and anastomosing bundles (tonofibrils) and also as single filaments about 40 A in thickness. These bundles were particularly well developed in the core of narrow cytoplasmic processes of tumor cells. The thickness and appearance of single tonofilaments were similar to those of the cytoplasmic microfilaments also observed in this study. It is suggested that the development of tonofilament bundles in the cytoplasmic processes of tumor cells may provide direct motive force for the deformation of the shape of the cell and potential invasiveness of these tumor cells.
对2例人支气管上皮鳞状细胞癌患者细胞中的张力丝进行了观察，并与正常支气管上皮细胞中的张力丝进行了比较。在正常组织中，仅观察到少量张力丝，且仅在上皮基底细胞中发现。在肿瘤细胞中，张力丝数量显著增加。它们以分支和吻合的束状（张力原纤维）形式出现在细胞质中，也以厚度约40埃的单丝形式出现。这些束在肿瘤细胞狭窄细胞质突起的核心部位特别发达。单根张力丝的厚度和外观与本研究中观察到的细胞质微丝相似。提示肿瘤细胞细胞质突起中张力丝束的形成可能为细胞形状的改变和这些肿瘤细胞的潜在侵袭性提供直接动力。
