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年龄、性别和昼夜变化对人体纤维蛋白溶解系统的影响。

Effect of age, sex, and diurnal variation on the human fibrinolystic system.

作者信息

Mann R D

出版信息

J Clin Pathol. 1967 May;20(3):223-6. doi: 10.1136/jcp.20.3.223.

DOI:10.1136/jcp.20.3.223
PMID:5602552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473472/
Abstract

Fibrinolytic activity, as shown by the dilute blood clot lysis time, tends to show a diurnal variation, but is relatively unaffected by age and sex. Mean plasma anti-urokinase activity is consistently and significantly greater in females in the post-menstrual week than in age-matched males, but is relatively unaffected by daily variation and age. This sex difference in the activity of plasma, which is inhibitory to fibrinolysis, is of a degree which makes this measurement important in studies of the fibrinolytic system in healthy persons and disease states.

摘要

如稀释血凝块溶解时间所示,纤溶活性往往呈现昼夜变化,但相对不受年龄和性别的影响。月经周期后一周女性的平均血浆抗尿激酶活性始终显著高于年龄匹配的男性,但相对不受每日变化和年龄的影响。血浆中这种抑制纤溶的活性存在性别差异,其程度使得该测量在健康人和疾病状态下纤溶系统的研究中具有重要意义。

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本文引用的文献

1
A method for determining serum inhibitors of plasminogen activation.一种测定纤溶酶原激活血清抑制剂的方法。
Scand J Clin Lab Invest. 1962;14:138-44. doi: 10.3109/00365516209079685.
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Studies on the thrombolytic activity of human plasma.人体血浆溶栓活性的研究。
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3
THE FIBRINOLYTIC SYSTEM DURING THE MENSTRUAL CYCLE.月经周期中的纤溶系统。
Obstet Gynecol. 1964 Jan;23:12-6.
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Increase of blood fibrinolytic activity by testosterone.睾酮对血液纤溶活性的增强作用。
Lancet. 1962 Jul 21;2(7247):128-32. doi: 10.1016/s0140-6736(62)90009-0.
5
Determination of fibrinolytic activity of whole blood. With special reference to the effects of exercise and fat feeding.全血纤溶活性的测定。特别提及运动和高脂饮食的影响。
Lancet. 1959 Oct 3;2(7101):471-5. doi: 10.1016/s0140-6736(59)90602-6.
6
Plasmin-antiplasmin complex as a reservoir of fibrinolytic enzyme.纤溶酶 - 抗纤溶酶复合物作为纤溶酶的储存库。
Am J Physiol. 1960 Sep;199:491-4. doi: 10.1152/ajplegacy.1960.199.3.491.
7
Studies on enhanced fibrinolytic activity in man.关于人类纤维蛋白溶解活性增强的研究。
J Clin Invest. 1959 May;38(5):810-22. doi: 10.1172/JCI103863.
8
Diurnal fluctuation of plasma-fibrinolytic activity in normal males.正常男性血浆纤维蛋白溶解活性的昼夜波动
Lancet. 1959 Mar 28;1(7074):660-2. doi: 10.1016/s0140-6736(59)92404-3.
9
Studies of the plasmin system. III. Physical properties of the two plasmin inhibitors in plasma.纤溶酶系统的研究。III. 血浆中两种纤溶酶抑制剂的物理性质。
J Exp Med. 1958 Nov 1;108(5):639-49. doi: 10.1084/jem.108.5.639.
10
Studies of the plasmin system. II. Inhibition of plasmin by serum or plasma.纤溶酶系统的研究。II. 血清或血浆对纤溶酶的抑制作用。
J Exp Med. 1958 Jul 1;108(1):53-68. doi: 10.1084/jem.108.1.53.