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11-顺式视黄醛结合蛋白仅存在于视网膜中。

Occurrence of 11-cis-retinal-binding protein restricted to the retina.

作者信息

Futterman S, Saari J C

出版信息

Invest Ophthalmol Vis Sci. 1977 Aug;16(8):768-71.

PMID:560359
Abstract

A binding protein for retinal (vitamin A aldehyde), the 11-cis-retinal-binding protein, was present in the soluble protein fraction of rat retina but was absent from brain, lung, heart, skeletal muscle, liver, kidney, spleen, small intestine, and testes. The binding protein was also found in human retina but not human liver. The binding protein for retinal from human retina did not bind retinol and was larger than, and readily separable from, the cellular retinol-binding protein which did not bind retinal. It would appear that the occurrence of a soluble binding protein for retinal, unlike the more widely distributed binding proteins for retinol and retinoic acid, may be unique to the retina.

摘要

一种视网膜(维生素A醛)结合蛋白,即11-顺式视网膜结合蛋白,存在于大鼠视网膜的可溶性蛋白组分中,但在脑、肺、心脏、骨骼肌、肝脏、肾脏、脾脏、小肠和睾丸中不存在。该结合蛋白也存在于人类视网膜中,但不存在于人类肝脏中。来自人类视网膜的视网膜结合蛋白不结合视黄醇,且比不结合视网膜的细胞视黄醇结合蛋白更大,并且易于与之分离。看来,视网膜可溶性结合蛋白的存在,与分布更广泛的视黄醇和视黄酸结合蛋白不同,可能是视网膜特有的。

相似文献

1
Occurrence of 11-cis-retinal-binding protein restricted to the retina.11-顺式视黄醛结合蛋白仅存在于视网膜中。
Invest Ophthalmol Vis Sci. 1977 Aug;16(8):768-71.
2
Retinol- and retinoic acid-binding proteins: occurrence in human retina and absence from human cultured fibroblasts.视黄醇和视黄酸结合蛋白:在人类视网膜中的存在以及在人类培养成纤维细胞中的缺失。
Invest Ophthalmol. 1976 Dec;15(12):1017-20.
3
Localization of cellular retinal-binding protein in bovine retina and retinal pigment epithelium, with a consideration of the pigment epithelium isolation technique.细胞视网膜结合蛋白在牛视网膜和视网膜色素上皮中的定位,并对色素上皮分离技术加以考量。
Invest Ophthalmol Vis Sci. 1977 Sep;16(9):797-806.
4
IRBP enhances removal of 11- cis -retinaldehyde from isolated RPE membranes.IRBP增强了从分离的视网膜色素上皮(RPE)膜中去除11-顺式视黄醛的能力。
Exp Eye Res. 2000 Feb;70(2):235-45. doi: 10.1006/exer.1999.0781.
5
Cellular retinol- and retinoic acid-binding proteins in transformed mammalian cells.转化哺乳动物细胞中的细胞视黄醇和视黄酸结合蛋白。
Invest Ophthalmol Vis Sci. 1978 Oct;17(10):988-92.
6
Support for a proposed retinoid-processing protein complex in apical retinal pigment epithelium.对视网膜色素上皮顶端一种拟议的类视黄醇加工蛋白复合物的支持。
Exp Eye Res. 2004 Sep;79(3):419-22. doi: 10.1016/j.exer.2004.04.001.
7
Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium.鉴定与来自牛视网膜和视网膜色素上皮的三种细胞视黄醇结合蛋白相关的内源性视黄醇。
J Biol Chem. 1982 Nov 25;257(22):13329-33.
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Occurrence of a binding protein for 11-cis-retinal in retina.
J Biol Chem. 1977 May 25;252(10):3267-71.
9
The presence of a soluble interphotoreceptor retinol-binding protein (IRBP) in the retinal interphotoreceptor space.视网膜感光细胞间间隙中可溶性感光细胞间视黄醇结合蛋白(IRBP)的存在。
J Cell Physiol. 1983 Dec;117(3):333-41. doi: 10.1002/jcp.1041170308.
10
Retinoid-binding proteins in retinoblastoma tumors.
Cancer Res. 1988 Mar 1;48(5):1124-8.

引用本文的文献

1
Chemistry of the retinoid (visual) cycle.视黄醛(视觉)循环的化学过程。
Chem Rev. 2014 Jan 8;114(1):194-232. doi: 10.1021/cr400107q. Epub 2013 Jul 11.
2
Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.博特尼亚营养不良是由细胞视黄醛结合蛋白突变体R234W中的多米诺样重排引起的。
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18545-50. doi: 10.1073/pnas.0907454106. Epub 2009 Oct 21.
3
A novel cone visual cycle in the cone-dominated retina.在以视锥细胞为主的视网膜中存在一种新型视锥细胞视觉循环。
Exp Eye Res. 2007 Aug;85(2):175-84. doi: 10.1016/j.exer.2007.05.003. Epub 2007 May 24.
4
Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina.脊椎动物视网膜中两种类视黄醇结合蛋白的免疫细胞化学定位
J Cell Biol. 1983 Sep;97(3):703-12. doi: 10.1083/jcb.97.3.703.