Andersson G, Heby O
Cancer Lett. 1977 Jul;3(1-2):59-63. doi: 10.1016/s0304-3835(77)94150-7.
Population kinetics of Ehrlich ascites tumor cells grown in vivo were studied following treatment with methylglyoxal-bis(guanylhydrazone) (MeGAG; NSC-32946), a potent chemotherapeutic agent and a specific polyamine synthesis inhibitor. MeGAG-treatment resulted in a continuous accumulation of cells in the S and G2 phases of the cell cycle, and, as a consequence, the rate of cell proliferation decreased. This finding emphasizes the importance of the polyamines for progression through the cell cycle.
在用甲基乙二醛双（脒腙）（MeGAG；NSC-32946）治疗后，对体内生长的艾氏腹水瘤细胞的群体动力学进行了研究。MeGAG是一种有效的化疗药物和特定的多胺合成抑制剂。MeGAG处理导致细胞在细胞周期的S期和G2期持续积累，结果细胞增殖速率下降。这一发现强调了多胺在细胞周期进程中的重要性。
