Kasschau M R, Elder J, Meyn R E
Chem Biol Interact. 1977 Aug;18(2):205-15. doi: 10.1016/0009-2797(77)90007-2.
Chinese hamster ovary (CHO) cells in vitro were treated with HgCl2 at various stages in the cell cycle and the effects of this chemical on cell survival, DNA replication, and cell division were observed. In terms of survival the early G1 cells were the most sensitive to treatment, followed by late G1 and early S, while mid S and late S-G2 treated cells were the least sensitive. Treatment with HgCl2 also resulted in reduced rates of DNA replication and delays in cell division. The early G1 treated cells showed substantially reduced rates of DNA replication followed by 4--5 h division delay. The early S and late S-G2 treated cells had some reduction in their rates of DNA replication followed by corresponding division delay of 2.5 h in the early S treated cells and 1 h in the late S-G2 treated cells.
体外培养的中国仓鼠卵巢（CHO）细胞在细胞周期的不同阶段用氯化汞处理，观察这种化学物质对细胞存活、DNA复制和细胞分裂的影响。就细胞存活而言，G1期早期的细胞对处理最为敏感，其次是G1期晚期和S期早期，而S期中期和S期晚期-G2期处理的细胞最不敏感。用氯化汞处理还导致DNA复制速率降低和细胞分裂延迟。G1期早期处理的细胞DNA复制速率大幅降低，随后出现4-5小时的分裂延迟。S期早期和S期晚期-G2期处理的细胞DNA复制速率有所降低，随后S期早期处理的细胞相应出现2.5小时的分裂延迟，S期晚期-G2期处理的细胞出现1小时的分裂延迟。
