Asbach H W, Holz F, Möhring K, Schüler H W
Clin Toxicol. 1977 Sep;11(2):211-9. doi: 10.3109/15563657708989834.
Previous experimental results have demonstrated the possibility of eliminating imipramine (14 C-IP) by hemodialysis. A simultaneous uptake of the substance by the polyvinyl chloride extracorporeal blood lines could be shown. Based on these results the imipramine absorption capacity of the blood lines and of the artificial kidney (Hollow Fiber Artificial Kidney, HFAK, Model 4) were studied. Imipramine (IP) absorption capacity of a usual blood-line set (arterial and venous, surface area 86,000 mm) was estimated to be 43 mg, and that of the HFAK to be 207 mg. Charcoal hemoperfusion (300 gm of coated activated coconut charcoal) eliminated more than 90% of IP from the blood within 3 hr if the initial IP blood concentration was 2 mg/ml. In comparison, lipid hemodialysis using 20% soybean oil as dialysate eliminated 95% of IP from the blood when the initial IP blood concentration was 1 mg/ml and 98% when the initial IP blood concentration was 2 mg/ml. In vivo studies on the elimination of IP by lipid (10%) hemodialysis demonstrated a substantial removal of the substance. Within 2 hr of treatment, 12% of the administered dose (75% of the LD50) was eliminated.
先前的实验结果已证明通过血液透析消除丙咪嗪（14C - IP）的可能性。可以显示聚氯乙烯体外血路会同时摄取该物质。基于这些结果，对血路和人工肾（中空纤维人工肾，HFAK，型号4）的丙咪嗪吸收能力进行了研究。一套普通血路（动脉和静脉，表面积86,000平方毫米）的丙咪嗪（IP）吸收能力估计为43毫克，HFAK的吸收能力为207毫克。如果初始IP血浓度为2毫克/毫升，木炭血液灌流（300克包膜活性炭椰子炭）在3小时内可从血液中消除超过90%的IP。相比之下，使用20%大豆油作为透析液的脂质血液透析，当初始IP血浓度为1毫克/毫升时，可从血液中消除95%的IP，当初始IP血浓度为2毫克/毫升时，可消除98%的IP。关于通过脂质（10%）血液透析消除IP的体内研究表明该物质被大量清除。在治疗的2小时内，消除了给药剂量（LD50的75%）的12%。
