Lie T S, Kim W I, Holst A, Grünn U, Rommelsheim K
Acta Hepatogastroenterol (Stuttg). 1976 Jul-Aug;23(4):262-6.
To find the feasibility of treatment for congenital bile duct atresia, we studied the usefullness of extracorporeal hemoperfusion over activated charcoal in canine obstructive jaundice. One, three and five weeks after ligation and disection of common bile duct in 5 dogs we performed the hemoperfusion over activated charcoal extracorporeally (group 3). In this animals we examined hematological and blood coagulation studies, serum electrolyte levels, kidney function tests and liver chemistries. As control in 5 animals we carried out after sham operation the perfusion without common bile duct ligation (group 2) and in 5 animals only common bile duct ligation without perfusion (group 1). In the liver chemistries we found 2 weeks after 2nd and 3rd perfusion (5 and 7 weeks after bile duct ligation) lower levels of serum bilirubin, GOT, GPT and SDH in treated group than in non-treated jaundiced animals. It suggest the effectiveness of hemoperfusion with activated charcoal in the treatment of occlusive jaundice. There were no alteration in the hematological studies, serum electrolyte levels and kidney function tests. PT and PTT was prolonged in the jaundiced animals there were no significant differences with and without hemoperfusion.
为了探究先天性胆管闭锁的治疗可行性，我们研究了活性炭体外血液灌注对犬梗阻性黄疸的有效性。在5只犬的胆总管结扎并切断后1周、3周和5周，我们对其进行了体外活性炭血液灌注（第3组）。在这些动物身上，我们检查了血液学和凝血研究、血清电解质水平、肾功能测试以及肝功能。作为对照，在5只动物身上进行了假手术后进行无胆总管结扎的灌注（第2组），在5只动物身上仅进行胆总管结扎而不进行灌注（第1组）。在肝功能检查中，我们发现第2次和第3次灌注后2周（胆管结扎后5周和7周），治疗组的血清胆红素、谷草转氨酶（GOT）、谷丙转氨酶（GPT）和山梨醇脱氢酶（SDH）水平低于未治疗的黄疸动物。这表明活性炭血液灌注在治疗阻塞性黄疸方面是有效的。血液学研究、血清电解质水平和肾功能测试均无变化。黄疸动物的凝血酶原时间（PT）和部分凝血活酶时间（PTT）延长，有无血液灌注之间无显著差异。
