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抗生素纺锤菌素对小鼠腹水瘤染色体的体外效应。

Effects of the antibiotic netropsin on mouse ascites tumour chromosomes in vitro.

作者信息

Wobus A M, Wobus U, Schöneich J

出版信息

Experientia. 1977 Sep 15;33(9):1212-3. doi: 10.1007/BF01922335.

DOI:10.1007/BF01922335
PMID:560986
Abstract

The antibiotic netropsin was found to induce an increase of the aberration frequency of up to 10% and a decondensation and elongation of centromeric regions of the chromosomes in mouse ascites tumour cells cultivated in vitro.

摘要

已发现抗生素纺锤菌素能使体外培养的小鼠腹水肿瘤细胞的畸变频率增加高达10%，并使染色体着丝粒区域解聚和伸长。

相似文献

1
Effects of the antibiotic netropsin on mouse ascites tumour chromosomes in vitro.抗生素纺锤菌素对小鼠腹水瘤染色体的体外效应。
Experientia. 1977 Sep 15;33(9):1212-3. doi: 10.1007/BF01922335.
2
Structural modifications induced in Chinese hamster V79--E chromosomes by prefixation treatment in vitro with the AT-specific agents netropsin, distamycin A, and Hoechst 33258.用AT特异性药物纺锤菌素、偏端霉素A和Hoechst 33258体外预处理诱导中国仓鼠V79-E染色体的结构修饰。
Hereditas. 1981;94(2):209-13. doi: 10.1111/j.1601-5223.1981.tb01754.x.
3
The effect of the mode of administration of nitrogen mustard and cytosine arabinoside on the production of chromosomal aberrations in mouse bone marrow and ascites tumour cells.氮芥和阿糖胞苷的给药方式对小鼠骨髓及腹水肿瘤细胞中染色体畸变产生的影响。
Mutat Res. 1978 Sep;58(1):67-77. doi: 10.1016/0165-1218(78)90096-4.
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Chromosomal alterations in the evolution of substrains of the Erhlich-Lettré-Mouse ascites tumour.
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Localization of AT-clusters in normal mouse chromosomes by netropsin prefixation treatment in vitro.通过体外纺锤菌素预固定处理对正常小鼠染色体中AT-簇进行定位。
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引用本文的文献

1
Familial fragility on chromosome 16 (fra 16q22) enhanced by both interferon and Distamycin A.
Hum Genet. 1983;63(4):341-4. doi: 10.1007/BF00274759.

本文引用的文献

1
[Application of manometry to the study of cell growth in Ehrlich-ascites tumor. Influence of the oxygen concentration on cell multiplication].
Acta Biol Med Ger. 1966;16(4):372-87.
2
Chromosomal localization of mouse satellite DNA.小鼠卫星DNA的染色体定位
Science. 1970 Jun 12;168(3937):1356-8. doi: 10.1126/science.168.3937.1356.
3
On the induction of segment extension and chromatid structural changes in Vicia faba chromosomes after treatment with 5-azacytidine and 5-azadeoxycytidine.关于用5-氮杂胞苷和5-氮杂脱氧胞苷处理后蚕豆染色体中片段延伸和染色单体结构变化的诱导
Mutat Res. 1970 Jun;9(6):599-606. doi: 10.1016/0027-5107(70)90105-3.
4
Chromosomal and nuclear location of mouse satellite DNA in individual cells.小鼠卫星DNA在单个细胞中的染色体和核定位。
Nature. 1970 Mar 7;225(5236):912-5. doi: 10.1038/225912a0.
5
Induction of chromosome crossbanding by treating cells with chemical agents before fixation.在固定前用化学试剂处理细胞诱导染色体交叉带。
Exp Cell Res. 1973 Jun;79(2):484-7. doi: 10.1016/0014-4827(73)90477-1.
6
A method for discriminating murine and human chromosomes in somatic cell hybrids.一种鉴别体细胞杂种中鼠类和人类染色体的方法。
Exp Cell Res. 1974 Oct;88(2):406-10. doi: 10.1016/0014-4827(74)90260-2.
7
Decondensation of constitutive heterochromatin in L cell chromosomes by a benzimidazole compound ("33258 Hoechst").一种苯并咪唑化合物（“Hoechst 33258”）使 L 细胞染色体中的组成型异染色质解聚。
Exp Cell Res. 1973 Oct;81(2):474-7. doi: 10.1016/0014-4827(73)90537-5.
8
Effects of the antibiotics netropsin and distamycin A on the structure and function of nucleic acids.抗生素纺锤菌素和偏端霉素A对核酸结构与功能的影响。
Prog Nucleic Acid Res Mol Biol. 1975;15(0):285-318. doi: 10.1016/s0079-6603(08)60122-1.
9
Duplex structure formation between oligo(dA)'s and oligo(dT)'s generated by thymine-specific interaction with netropsin.由嗜中性霉素与胸腺嘧啶的特异性相互作用所产生的寡聚（dA）与寡聚（dT）之间的双链结构形成
Nucleic Acids Res. 1976 Jun;3(6):1521-32. doi: 10.1093/nar/3.6.1521.
10
Theoretical calculations of the helix-coil transition of DNA in the presence of large, cooperatively binding ligands.在存在大的、协同结合配体的情况下DNA螺旋-卷曲转变的理论计算。
Biopolymers. 1976 Jul;15(7):1345-75. doi: 10.1002/bip.1976.360150710.