由嗜中性霉素与胸腺嘧啶的特异性相互作用所产生的寡聚（dA）与寡聚（dT）之间的双链结构形成
Duplex structure formation between oligo(dA)'s and oligo(dT)'s generated by thymine-specific interaction with netropsin.
作者信息
Zimmer C, Luck G, Fric I
出版信息
Nucleic Acids Res. 1976 Jun;3(6):1521-32. doi: 10.1093/nar/3.6.1521.
Abstract
The formation of oligomeric duplex molecules in the presence of the antibiotic netropsin in the series p(dA)n-p(dT)n is demonstrated using low-temperature CD measurements. Addition of Netropsin to mixtures of oligomers generates the same type of CD spectra as observed for poly(dA)-poly(dT) and maintains the duplex structure at temperatures at which base pairing of free oligomers is thermodynamically unstable. The shortest chain length forming a netropsin complex by thymine-specific interaction with the oligopeptide is represented by p(dA)4-p(dt)4. Studies with sequence isomers show that adjacent thymine residues strongly favour the complex formation with the oligopeptide.
摘要
利用低温圆二色性测量证明了在抗生素纺锤菌素存在下，p(dA)n-p(dT)n系列中寡聚双链分子的形成。将纺锤菌素添加到寡聚物混合物中会产生与聚(dA)-聚(dT)所观察到的相同类型的圆二色光谱，并在游离寡聚物的碱基配对在热力学上不稳定的温度下维持双链结构。通过与寡肽的胸腺嘧啶特异性相互作用形成纺锤菌素复合物的最短链长由p(dA)4-p(dt)4表示。对序列异构体的研究表明，相邻的胸腺嘧啶残基强烈有利于与寡肽形成复合物。
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Duplex structure formation between oligo(dA)'s and oligo(dT)'s generated by thymine-specific interaction with netropsin.由嗜中性霉素与胸腺嘧啶的特异性相互作用所产生的寡聚（dA）与寡聚（dT）之间的双链结构形成
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本文引用的文献
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CD studies on the conformation of some deoxyoligonucleotides containing adenine and thymine residues.关于一些含有腺嘌呤和胸腺嘧啶残基的脱氧寡核苷酸构象的圆二色性研究。
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Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.纺锤菌素和偏端霉素与DNA及DNA模型聚合物的构象依赖性结合
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[Comparison of oligoribonucleotides and oligodesoxyribonucleotides. I. Formation of double helices].[寡核糖核苷酸与寡脱氧核糖核苷酸的比较。I. 双螺旋的形成]
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The organization of highly repeated DNA sequences in Drosophila melanogaster chromosomes.黑腹果蝇染色体中高度重复DNA序列的组织方式。
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Effects of the antibiotics netropsin and distamycin A on the structure and function of nucleic acids.抗生素纺锤菌素和偏端霉素A对核酸结构与功能的影响。
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(dA-dT) dependent inactivation of the DNA template properties by interaction with netropsin and distamycin A.通过与纺锤菌素和偏端霉素A相互作用，（dA-dT）依赖性地使DNA模板特性失活。
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