Miyazawa M
Gastroenterol Jpn. 1977;12(2):8-19. doi: 10.1007/BF02773620.
Ulcerogenic stimulations such as histamine and restraint water immersion stress were given to rats after the gastric ulcers were made by the clamping method. Development of the stress and histamine ulcers were distinctly inhibited after the clamping ulcers were made, and this inhibition reached a maximum at the 7th clamping ulcer day and lowered gradually thereafter. In control rats, the stress and histamine ulcers usually develop in the lesser curvature, but in animals with the clamping ulcers they develop in the greater curvature where the clamping ulcer was made. The histological changes of the stress ulcers in the stomach with the clamping ulcer were slighter compared with those of the control (without clamping ulcers) rats. Furthermore, the relationships between the development of the stress ulcers and the changes of the uronic acid content in the stomach were observed. The uronic acid content increased after the clamping ulcer was made and reached a maximum at the 7th clamping ulcer day. Thereafter it began to decrease and returned to the normal level. From the results of the studies, it was strongly suggested that the mechanism of inhibition to development of the stress ulcers might be attributed to an increase of acid mucopolysaccharide in the gastric wall after the clamping ulcer was induced.
采用夹闭法造成大鼠胃溃疡后，再给予组胺和束缚水浸应激等致溃疡刺激。夹闭性溃疡形成后，应激性和组胺性溃疡的发展明显受到抑制，这种抑制在夹闭性溃疡形成后的第7天达到最大，此后逐渐降低。在对照大鼠中，应激性和组胺性溃疡通常发生在胃小弯处，但在有夹闭性溃疡的动物中，它们发生在形成夹闭性溃疡的胃大弯处。与对照（无夹闭性溃疡）大鼠相比，有夹闭性溃疡的胃中应激性溃疡的组织学变化较轻。此外，还观察了应激性溃疡的发展与胃中糖醛酸含量变化之间的关系。夹闭性溃疡形成后，糖醛酸含量增加，并在夹闭性溃疡形成后的第7天达到最大。此后它开始下降并恢复到正常水平。从研究结果强烈提示，应激性溃疡发展受到抑制的机制可能归因于诱导夹闭性溃疡后胃壁中酸性粘多糖的增加。
